For more discussion on the IV/PO decision, see Brad Spellberg’s site. (https://www.bradspellberg.com/oral-antibiotics)
Bacteremia
Trials
- Early switch to PO beta-lactams was safe and efficacious in selected low-risk MSSA: bacteremia cases: Bupha-Intr et al. Antimicrob Agents Chemother 2020;64:e02345-19.
- Early switch to PO linezolid in low-risk SAB: no difference in 90-day relapse: Willekens et al. Clin Infect Dis. 2019;69:381-387.
- PO antibiotic for Gm- bloodstream infections: no difference between FQs, TMP-SMX, or beta-lactams: Kutob et al. Int J Antimicrob Agents. 2016;48(5):498-503.
- Oral stepdown for Enterobacteriaceae-associated bacteremic UTI: Rieger et al. Pharmacotherapy. 2017;37(11):1479-1483.
- Oral stepdown for Enterobacteriaceae: FQ = beta-lactams: Mercuro et al. Int J Antimicrob Agents. 2018;51(5):687-692.
- 5 day oral stepdown for Gm- bacteremia = all IV therapy regarding 30-day mortality and recurrence, with source control and clinical response: Tamma et al JAMA Intern Med. 2019;179(3):316-323.
- FQ = beta-lactams for oral step down therapy for Strep bacteremia: Arensman et al. Antimicrob Agents Chemother 2020;64(11):e01515-20.
- Switch to oral = IV for MRSAB: Jorgensen et al. J Antimicrob Chemother. 2019;74(2):489-498.
- Oral switch = IV for SAB: Perez-Rodriguez et al. Int J Infect Dis. 2020.
- Oral beta-lactam = FQ or TMP-SMX for Enterobacteriaceae bacteremia with suspected urine source: Sutton et al. JAMA Netw Open. 2020;3(10):e2020166.
Ortho
- SA-infected orthopedic implants with fusidic acid or oflaxacin + rifampin: Drancourt et al. J Antimicrob Chemother. 1997;39:235-240.
- Switch to PO = >4 weeks of IV for S. aureus OM, better with rifampin either with IV or PO: Daver et al. J Infect 2007:54;539-544.
- Early switch to oral for VOM: Babouee Flury et al. BMC Infect Dis 2014;14:226.
Other
- PO FQ + rifampin vs. flucloxacillin or vancomycin for staphylococcal infection (general): Schrenzel et al. Clin Infect Dis. 2004;39:1285-1292.
- Cipro PO ER daily for cUTI and pyelonephritis: Talan et al. J Urol. 2004;171(2 Pt 1):734-739.
- Oral antibiotic were noninferior to IV antibiotic for Klebsiella liver abscess (duration 28 days): Molton et al. Clin Infect Dis 2020;71(4):952-959.