Guideline
- Skin and Soft Tissue Infections Stevens et al. Clin Infect Dis. 2014;59(2):e10–e52.
Review articles
- Necrotizing soft-tissue infections: Stevens et al. N Engl J Med 2017;377:2253-2265.
- Skin abscesses in the era of MRSA: Singer et al. N Engl J Med 2014;370:1039-1047.
- What diagnostic strategies can help differentiate cellulitis from other causes of red legs in primary care? BMJ 2020;368:m54
Trials
- Antibiotics may not be necessary after I&D of SSTI abscess (it was cephalexin = placebo but 90% of isolates were MRSA): Rajendran et al. Antimicrob Agents Chemother 2007; 51:4044-8.
- TMP-SMX after I&D of uncomplicated skin abscess did not reduce treatment failoure but may decrease new lesions: Schmitz et al. Ann Emerg Med 2010; 56:283-7.
- TMP-SMX and clindamycin were equivalent for treating uncomplicated skin infections (cellulitis or large abscesses) in adults and children: Miller et al. N Engl J Med. 2015 Mar 19;372(12):1093-103.
- TMP-SMX was equivalent to clindamycin in efficacy for wound infections in setting where MRSA is prevalent; clindamycin had slightly less recurrences: Talan et al. Clin Infect Dis 2016;62(12):1505-1513.
- TMP-SMX was superior to placebo for abscesses after I&D: Talan et al. N Engl J Med 2016;374(9):823-832.
- TMP-SMX and clindamycin were equivalent, and better than placebo, in treating small skin abscesses after I&D in adults and children; TMP-SMX had fewer adverse effects: Daum et al. Open Forum Infect Dis 2016;3(suppl_1):1684.
- Same trial as above, published again?? Daum et al. N Engl J Med. 2017 Jun 29;376(26):2545-2555.
- 10 days was better than 5 or 7 days of antibiotic for SSTI infection after I&D; abscess size did not affect cure rates: Lake et al. Clin Infect Dis. 2020;71(3):661-663.
- 6 days tedezolid = 10 days linezolid for acute uncomplicated skin and skin structure infections
- Prokocimer et al. J Am Med Assoc 2013; 309:559–69.
- 6 days tedezolid (IV to PO) = 10 days linezolid (IV to PO) for acute uncomplicated skin and skin structure infections: Moran et al. Lancet Infect Dis 2014;14(8):696–705.
- Dose of IVIg for streptococcal necrotizing SSTI: Bersten et al. Clin Infect Dis. 2020;71(7):1772-1775.
Articles
- Drugs for MRSA SSTI: JAMA 2014;312(15):1583-1584. reprinted from Med Lett Drugs Ther. 2014;56(1442):39-40.
- Comparion table of drugs for MRSA SSTI: Med Lett Drugs Ther. 2018;60(1543):e59-62.
Blog Posts
Discusses the Daum trial for antibiotics for small abscesses (above): https://blogs.jwatch.org/hiv-id-observations/index.php/antibiotics-small-abscesses-now-theres-answer/2016/10/29/
Review articles
- Cellulitis (great pics of ddx): Raff et al. J Am Med Assoc 2016;316(3):325-337.
- Cellulitis masqueraders: Falagas et al. Ann Int Med 2015;142;47-55.
- Cellulitis mimics: Keller et al. Clev Clin J Med 2012;79(8):547-552.
- Cellulitis: Swartz. N Engl J Med 2004;350:904-912.
- How to differentiate cellulitis from other causes of red leg in outpt setting: Edwards et al. BMJ 2020;368:m54.
Trials
- TMP-SMX + cephalexin was not better than cephalexin alone for uncomplicated cellulitis: Moran et al. JAMA. 2017 May 23;317(20):2088-2096.
- Costs and consequences associated with misdiagnosed LE cellulitis: Weng et al. JAMA Dermatol. 2017;153:141.
- ID consultation improves outcomes for outpts with cellulitis in the ED: Jain et al. Diagn Micro Infect Dis. 2017;87:371.
- Dermatology consultation improves outcomes for inpts with cellulitis: Ko et al. JAMA Dermatol 2018;154(5):529-536.
- 5 days levofloxacin = 10 days levofloxacin for uncomplicated cellulitis in outpt setting: Hepburn et al. Arch Intern Med 2004; 164:1669–74.
- In 6 vs. 12 days for hospitalized severe cellulitis, could not confirm non-inferiority but 6 days had more relapses. used low-dose flucloxacillin: Cranendonk et al. Clin Microbiol Infect. 2020;26(5):606-612.
Tweetorials
Staph scalded skin syndrome
Cellulitis pearls
Cellulitis, thorough